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From350US$ /night
Check-in
26Oct2025Select date
Check-out
27Oct2025Select date
Rooms and Guests2 Guests, 1 Room
Key details

Hotel Overview

1528 Locust Street, Saint Louis, Missouri, United States, 63103

21C Museum Hotel St Louis - 4-star art-focused hotel near St Louis Gateway Arch

Located in Downtown St. Louis, this hotel is a 15-minute walk from Union Station and 2.5 km from St Louis Gateway Arch. The property features a 24-hour fitness center, historic indoor pool, and an on-site restaurant serving Spanish-inspired tapas. Guests have access to free Wi-Fi, original artwork by Missouri-based artists, and pet-friendly rooms. The hotel includes a contemporary art museum open 24/7. St Louis Lambert International Airport is the nearest airport, located approximately 20 km away.

Additional perks of the hotel

Locust Street Athletic and Swim Club with sauna and steam rooms

Small-group training sessions and personal training available

Monthly Coffee Talks on social impact and equity

Free museum tours and curated art exhibitions

On-site Idol Wolf restaurant with seasonal Midwestern-Spanish cuisine

Rooms overview

The hotel offers several room types, including Deluxe King, Luxury Double Queen, and Corner King Suite. All rooms feature air conditioning, a seating area, a wardrobe, a safe deposit box, and a flat-screen TV with streaming services. The 21c King Suite is a two-story duplex with a living and dining area, fireplace, and kitchenette. The Luxury King Suite includes a separate living area with a table and office, plus a bathroom with dual sink vanity and soaking tub.

Other conveniences

Malin+Goetz bath amenities and bathrobes

Northwest Coffee in rooms

50'' HDTV flat-screen television

Alarm clock/docking station

Laundry service and in-room dining available

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Choose Your Room

Our listed hotels offer a variety of room types—double rooms, family suites, or deluxe options—all with features like breakfast, flexible cancellation policies, and exclusive deals.
Corner King Room
2 persons
30 m² 
1 King-size bed
Shower
Heating
Deluxe King Room
2 persons
29 m² 
1 King-size bed
Shower
Heating
Corner King Suite
2 persons
44 m² 
1 King-size bed
Shower
Heating
Deluxe King Suite Roll Shower Accessible
2 persons
47 m² 
1 King-size bed
Shower
Heating
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Transportation Tips

Transportation Options

City Centre
Saint Louis600 m
Airports
Lambert (STL) 21.8 km
MidAmerica St. Louis/Scott Air Force Base (BLV) 40.8 km
Train
Union Station700 m
Bus
Bus stop200 m

Amenities

Thoughtful hotel amenities for a comfortable stay

General

  • No smoking on site
  • Free Wi-Fi
  • Safe deposit box
  • 24-hour reception
  • VIP check-in/ -out
  • Pets allowed
  • Rooms/ Facilities for disabled
  • Wheelchair access
  • 24-hour security
  • Luggage storage
  • Locker room
  • Allergy-free rooms
  • Lift
  • ATM/Cash machine
  • Coffee shop
  • Vending machines
  • Smoke detectors
  • Fire extinguishers
  • Key card access

Sports & Fitness

  • Fitness centre
  • Billiard tables
  • Yoga class

Services

  • Valet parking
  • Room service
  • Housekeeping
  • Laundry
  • Dry cleaning
  • Welcome drink

Dining

  • Restaurant
  • Bar/ Lounge area
  • Special diet menus

Business

  • Business centre
  • Meeting/ Banquet facilities

Children

  • Cots
  • Board games
  • Game room

Facilities for people with disabilities

  • Toilet for disabled

Spa & Leisure

  • Indoor swimming pool
  • Leisure/ TV room
  • Spa & wellness centre
  • Steam room
  • Jacuzzi
  • Massage

Room features

  • Air conditioning
  • Heating
  • Soundproofed rooms
  • Sitting area
  • Terrace
  • Garden furniture

Bathroom

  • Free toiletries

Media

  • Flat-screen TV
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Hotel Location

1528 Locust Street, Saint Louis, Missouri, United States, 63103
Map view
1528 Locust Street, Saint Louis, Missouri, United States, 63103
Nearby
Museum
City Museum
520 m
Museum
Campbell House Museum
90 m
Church
Christ Church Cathedral
430 m
1315 Chestnut St
Soldiers Memorial Military Museum
590 m
Aquarium
World Aquarium
400 m
Church
Centenary United Methodist Church
190 m
Night club
The Boom Boom Room
280 m
13th and Locust
Lucas Garden Park
350 m
Restaurants
The Last Kitchen
360 m
1501 Washington Ave Inside The Last Hotel
Red Oak Biscuits
310 m
1330 Washington Ave
Nara Cafe and Hookah Lounge
310 m
1326 Washington Ave
Flannery's
380 m
1324 Washington Ave
Rooftop Cafe at City Museum
400 m
701 N 15th St Fl 11
Lucas Park Grille
440 m
1234 Washington Avenue
Rosalita's Cantina
480 m
1235 Washington Avenue
Blondie's Coffee
450 m
1301 Washington Ave
Imo's Pizza
410 m
1828 Washington Ave
Papa John's Pizza
610 m
201 N Tucker Blvd Ste E
Bootleggin' BBQ
650 m
1933 Washington Ave
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Check-in
26Oct2025Select date
Check-out
27Oct2025Select date
Rooms and Guests2 Guests, 1 Room